Propofol

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Propofol = 2,6- diisopropyl phenol

1% / 2% emulsion in a lipid vehicle containing soybean oil, egg lecithin, and glycerol.

therefore - bacterial growth (thus discard after 6hrs)
Only IV use.

Pain on injection which can be decreased by :

1. injecting in larger vein.
2. Mixing with lignocaine
3. by cooling propofol

Other points:

• Recovery is rapid and clear (Therefore DOC for Day Care Surgery)

• Hepatic and Extrahepatic (Lungs) clearance.

• Decrease BP and Decrease Heart rate ( propofol blunts carotid body receptor response & hence no compensatory increase in heart rate)

• Causes maximum depression of upper airway reflexes (therefore DOC - for LMA insertion)

• Antiemitic & Antipruritic

• No anticonvulsant.

• Decrease IOP.(intraoccular pressure)

• AntiOxidant

• DOC in hepatic disease/Liver transplant (because it can be metabolized extrahepatic too.)

• Potentiates NMDR and fentanyl.

• DOC in Acute intermittent porphyria (here Thiopentone is Contraindicated)

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Propofol Infusion syndrome :

Triad of

• Metabolic Acidosis
• Skeletal Myopathy
• Acute Cardiomyopathy

On prolonged infusion (>48hrs) of high dose in child.

Occurs due to failure of metabolism of free fatty acids.

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