0 Halothane

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Halothane :

• Spontaneous oxidative decomposition retarded by - thymol preservative.

• Smooth induction

• Least decrease in Systemic vascular resistance.

• Lowers CO by direct myocardial depression

• Decrease HR

• Enhances myocardial sensitivity to dysrhythmogenic effects of epinephrine. (therefore not given in Pheochromocytoma)

• Reacts with metals in Vaporizers in presence of moisture.

• Maximum reduction in total hepatic blood flow and portal vein flow.

• Fast and shallow breathing

• Severe depression of hypoxic ventilatory drive.

• Potent Bronchodialator

• Depresses mucociliary function (Remember : Ether maintains ciliary function)

• Cerebro Vasodialator

• Prior hyperventilation required (to prevent increase in ICT)

• No Pain relief

• Uterine relaxant (Therefore DOC for Manual removal of placena ) ; (can cause PPH)

• Halothane hepatitis - Centrilobular necrosis (Inhalational agent of choice then is Sevoflurane)

Contraindications:

1. Malignant hyperthermia
2. Liver Dysfunction
3. Hypovolemia
4. Intra crania mass
5. Aortic Stenosis
6. Pheochromocytoma
7. with Aminophyline

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