Local Anaesthetics :
ESTERS
|
AMIDES
|
Procaine
Chloroprocaine (shortest acting)
Tetracaine
|
Lidocaine
Mepivacaine
Prilocaine
Bupivacaine
Etidocaine
Dibucaine (Longest acting)
|
Metabolized by Pseudocholinesterase( Plasma) (except Cocaine which is metabolized in liver)
|
Metabolized in Liver
|
Unstable
|
Stable
|
Metabolized to PABA – therefore Allergy
|
Low incidence of allergy
|
Mnemonic : EPPP
|
Bind to Alpha1 glycoprotein in plasma
More intense and longer lasting anaesthesia
|
MedicoNotebook - Founder : DrShiviMudgal , Co-Founder : DrAyushGoel
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