NDMR (some more points)

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Non-depolarizing Muscle relaxants :

This is the second post on NDMR.
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Drugs which antagonize the NDMR block :

1. Phenytoin
2. Carbamazepine
3. Calcium

Reversal of Block by :

1. Neostigmine

• does not cross BBB
• Muscarinic side effects - therefore give Atropine along with it.

2. Edrophonium

• Short duration of action (therefore chances of recurarization)

3. Pyridostigmine

• Longer duration

Signs of Adequate reversal :

1. Lift head for >5sec - Best Clinical Sign
2. Regular respiration
3. Spontaneous eye opening
4. Spontaneous Limb movements
5. Can protrude tongue
6. Able to cough
7. No Cyanosis

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