Some Diseases and Anaesthesia

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Porphyria :

Contraindicated drugs - 

• Thiopentone
• Etomidate
• Pentazocine

DOC - Propofol


Myesthenia Gravis :

• Increased sensitivity to NDMR
• Resistance to DMR
• Sevoflurane is inhalational agent of choice
• Atracurium (1/10th normal dose) is Muscle relaxant of choice.
• Risk of post-op Respiratory failure.

Dystrophia Myotonica:

• Tendency of Obstructive sleep apnea
• Sch is Contraindicated (as it causes prolonged contraction)
• Rapid sequence induction with Propofol and Rocuronium is used.

Duchenne Muscular Dystrophy :

• Abnormal response to Sch and Volatile agents
• IV induction preferred
• Hyperkalemia common
• NDMR duration is prolonged.

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