TORCH infections

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TORCH infections

Toxoplasma

Others

• Syphilis
• HIV
• Hep B
• Varicella

Rubella
CMV
Herpes

If Mother gets Rubella after 16wks - Nothing to fetus
But if 10-11 wks - Increased chances of fetal abnormalities

Common points :
1. 50 - 60 % are asymptomatic
2. If symptomatic :

• IUGR
• Failure to thrive
• Anaemia
• HepatoSpleenomegaly
• Thrombocytopenia
• Rash
• Cholestasis

Infectivity 
1. All of them - at time of delivery.
2. Rubella - 2 peaks -

• 10-11 wks
• At time of delivery

If HIV to mother - 

• Zidovudine after 14 wks pregnancy
• then For delivery - do elective LSCS
• If in labor - intrapartum Nevirapine
• Neverapine to child (oral) x 4-6wks

Diagnosis is based on Serology :

1. IgM - is made by the child itself

2. IgG - is transmitted from mother 

     Considered marker only if :

• IgG persists 6-9 months
• or increases in titre

Note : in HIV cases - 

• No IgM in child
• IgG persisting >18months is taken as marker. (not 6-9 months)

Thus for 1st 18 months : (as Child of HIV mother will be having +ve ELISA)

• p24 assay
• PCR (best but difficult)
• Viral Culture

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