0 Anticipation

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In genetics, anticipation is a phenomenon whereby the symptoms of a genetic disorder become apparent at an earlier age as it is passed on to the next generation. In most cases, an increase of severity of symptoms is also noted.

i.e with next generation

• Age of presentation decreases
• Severity of disorder increases.

eg : All trinucleotide repeat disorders

1. Fragile X ( CGG repeat) { here this anticipation phenomenon is termed Sherman Paradox }
2. Friedreich ataxia (GAA)
3. Myotonic Dystrophy ( CTG )
4. Spinobulbar Muscular Atrophy ( CAG)
5. Huntington's (CAG)
6. Spinocerebellar Ataxia (CAG/CTG)

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