0 Medical One Liners 131 - 140

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131. Cat eye syndrome :

• Partial trisomy of chromosome 22
• Vertical oval pupil due to inferior iris coloboma

132. Single S2 in Tetrology of fallot.

133. All newborns have right ventricular hypertrophy and right axis deviation.

134. AA which have a pKa of 4 - aspartic acid and glutamic acid

135. Topoisomerase I (relaxase) 

• makes ssDNA cuts, 
• requires no ATP, 
• relaxes supercoils, and 
• acts as the swivel in front of the replication fork

136. 10 ATPs are generated per acetylCoA. (3NADH + 1FADH2 + 1GTP) {NADH = 2.5ATP; FADH2 = 1.5ATP}

137. Ketogenic AAs - Leucine and Lysine

138. Thiamine pyrophosphate (TPP) associated enzymes :

• Alpha-ketoglutarate dehydrogenase
• Pyruvate dehydrogenase
• Transketolase

139. DNA replication occurs during S phase of the cell cycle.

140. Rise in conjugated (direct) bilirubin seen in Rotor syndrome and Dubin–Johnson syndrome.

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