Celiac disease

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Celiac disease ( Coeliac disease )

• Gluten sensitivity 
  Thus if wheat is introduced in diet , there can be -
  1. Chronic Diarrhoea
  2. Recurrent diarrhoea
  3. Abdominal distention
  4. Vomiting
  5. Anorexia
  6. Failure to thrive
• Can be asymptomatic
• Age group : 6 months - 24 months

MCQ point - HLA DQ2 , DQ8

MARSH Criteria 

1. Disease of small intestine in which
   - Villous atrophy
   - Crypt hyperplasia
   - Transmural inflammation
2. If restrict gluten - mucosa returns to normal
3. If gluten challenge - mucosa goes back to original state

Best Test :

1. Anti Endomysial Antibody (Specificity 97 - 100%)
2. Anti TTG (Tissue transglutaminase antibody )

Serum IgA levels are low

Treatment : Life long gluten restriction
i.e NO TO - Wheat , Barley and Rye.

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